Schott K, Wormstall H, Dietrich M, Klein R, Batra A
Psychiatrische Universitatsklinik, Tubingen, Germany.
Psychiatry Res. 1996 Jan 31;59(3):251-4. doi: 10.1016/0165-1781(95)02703-3.
Serum antibodies against a series of antigens, including an organ-specific central nervous system (CNS) antigen and the neurotransmitter serotonin, were investigated in 22 patients with Alzheimer's Disease (n=15) and other age-related dementias (n=7) by indirect immunofluorescence assay and enzyme-linked immunosorbent assay. Patients with dementia showed an increase of antibody-positive sera against nuclear antigen, gastric parietal cells, CNS antigen, gangliosides (Gm1), laminin, and keratin. Alzheimer's Disease patients alone exhibited antibodies against CNS antigen. However, the results do not show sufficient specificity and sensitivity for use as a diagnostic indicator.
通过间接免疫荧光测定法和酶联免疫吸附测定法，对22例阿尔茨海默病患者（n = 15）和其他与年龄相关的痴呆患者（n = 7）进行了针对一系列抗原的血清抗体检测，这些抗原包括一种器官特异性中枢神经系统（CNS）抗原和神经递质血清素。痴呆患者显示出针对核抗原、胃壁细胞、CNS抗原、神经节苷脂（Gm1）、层粘连蛋白和角蛋白的抗体阳性血清增加。仅阿尔茨海默病患者表现出针对CNS抗原的抗体。然而，这些结果作为诊断指标的特异性和敏感性不足。
