Chapman J, Sela B A, Wertman E, Michaelson D M
Department of Biochemistry, Faculty of Life Sciences, Tel-Aviv University, Ramat, Israel.
Neurosci Lett. 1988 Mar 31;86(2):235-40. doi: 10.1016/0304-3940(88)90577-0.
Gangliosides are thought to have a role in neuronal development and regeneration while anti-ganglioside antibodies have been shown to impair these processes. In the present work we examined whether the neuronal degeneration in Alzheimer's disease is associated with the presence of anti-ganglioside antibodies. A significant level of antibodies specific to ganglioside GM1 but not to other gangliosides (GD1a, GD1b, GT1b and GQ1b) was found in patients with Alzheimer's disease as compared to normal age matched controls. A high level of antibodies to GM1 was also found in patients with multi-infarct dementia and Parkinson's disease with dementia but not in non-demented patients with other neurodegenerative diseases. These results may reflect a specific change in ganglioside metabolism which is associated with the neurodegenerative processes underlying Alzheimer's disease and other causes of dementia.
神经节苷脂被认为在神经元发育和再生中起作用，而抗神经节苷脂抗体已被证明会损害这些过程。在本研究中，我们检测了阿尔茨海默病中的神经元变性是否与抗神经节苷脂抗体的存在有关。与年龄匹配的正常对照组相比，在阿尔茨海默病患者中发现了针对神经节苷脂GM1而非其他神经节苷脂（GD1a、GD1b、GT1b和GQ1b）的显著水平抗体。在多发性梗死性痴呆和帕金森病痴呆患者中也发现了高水平的GM1抗体，但在患有其他神经退行性疾病的非痴呆患者中未发现。这些结果可能反映了神经节苷脂代谢的特定变化，这与阿尔茨海默病及其他痴呆病因背后的神经退行性过程有关。
