猪骨骼肌兰尼碱受体基因结构的编码区1至10614，包含71个外显子。

The porcine skeletal muscle ryanodine receptor gene structure coding region 1 to 10614 harbouring 71 exons.

作者信息

Wen G, Leeb T, Reinhart B, Schmoelzl S, Brenig B

机构信息

Institute of Veterinary Medicine, University of Goettingen, Germany.

出版信息

Anim Genet. 1996 Oct;27(5):297-304. doi: 10.1111/j.1365-2052.1996.tb00973.x.

DOI:10.1111/j.1365-2052.1996.tb00973.x

PMID:8930069

Abstract

The skeletal muscle ryanodine receptor (RYR1) belongs to a family of calcium release channels that are expressed in different tissues. The RYR1 gene is one of the largest genes characterized, so far, containing a 15253 nucleotide ORF in swine. To study the genomic organization of the porcine skeletal muscle ryanodine receptor gene we have isolated seven genomic fragments spanning 72.7 kb of chromosomal DNA of chromosome 6q12. This region harbours exons 1 to 71 coding for 3538 amino acids (69.6%) of the ryanodine receptor 1.

摘要

骨骼肌兰尼碱受体（RYR1）属于在不同组织中表达的钙释放通道家族。RYR1基因是迄今为止已鉴定的最大基因之一，在猪中包含一个15253个核苷酸的开放阅读框。为了研究猪骨骼肌兰尼碱受体基因的基因组结构，我们分离出了7个基因组片段，这些片段跨越6号染色体q12区域的72.7 kb染色体DNA。该区域包含编码兰尼碱受体1的3538个氨基酸（69.6%）的第1至71外显子。