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1,2,3-Triazolo [4,5-d] pyridazines--V. Preparation and adenosine receptor binding of new 4-amino derivatives.

作者信息

Biagi G, Giorgi I, Livi O, Manera C, Scartoni V, Lucacchini A, Senatore G

机构信息

Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Pisa.

出版信息

Farmaco. 1996 Aug-Sep;51(8-9):601-8.

PMID:8930114
Abstract

This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyridazine derivatives which had shown binding affinity towards A1-adenosine receptors. 1-Benzyl derivatives bearing new amines and new 1-(substituted benzyl) derivatives were prepared and tested. The biological results showed that some compounds possessed high affinity (approximately 30-70 nM) and good selectivity toward the A1-adenosine receptors. Further information about structure-biological activity relationships was aquired.

摘要

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