Gandolfo G, Schweitz H, Lazdunski M, Gottesmann C
Laboratoire de Psychophysiologie, Faculté des Sciences, Nice Cedex 2, France.
Brain Res. 1996 Oct 14;736(1-2):344-7. doi: 10.1016/0006-8993(96)00690-7.
Intracerebroventricular injections of low doses of apamin, a specific blocker of a class of Ca(2+)-activated K+ channels, induced insomnia and a long-lasting suppression of deep slow sleep and paradoxical sleep. Injected animals showed a late but important rebound of paradoxical sleep. Even after the recovery of a normal sleep amount, the circadian cycle remained disturbed during all the recording duration (96 h).
脑室内注射低剂量蜂毒明肽（一类钙激活钾通道的特异性阻滞剂）会导致失眠，并对深度慢波睡眠和异相睡眠产生长期抑制。注射后的动物表现出异相睡眠的延迟但重要的反弹。即使在恢复正常睡眠量后，在整个记录期间（96小时）昼夜节律仍受到干扰。
