van der Reijden W A, van der Kwaak J S, Veerman E C, Nieuw Amerongen A V
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), The Netherlands.
Eur J Oral Sci. 1996 Aug;104(4 ( Pt 1)):335-40. doi: 10.1111/j.1600-0722.1996.tb00088.x.
In Sjögren's syndrome, salivary glands are affected, resulting in a diminished salivary flow. In the present study, the protein composition, sialic acid content and the amounts of calcium and phosphate of stimulated whole saliva from 43 patients with Sjögren's syndrome, were compared with those of control saliva samples from 17 healthy subjects. The absolute concentrations of albumin, cystatin C, cystatin S, total IgA and total protein, but not amylase, were increased significantly in both primary and secondary Sjögren's syndrome. The output/min of total protein, albumin, amylase, and IgA was, however, decreased in Sjögren patients. These results suggest that the diminished output of salivary defence factors, rather than their absolute concentrations, may be related to the oral health problems seen in Sjögren's syndrome patients.
在干燥综合征中，唾液腺会受到影响，导致唾液分泌减少。在本研究中，将43例干燥综合征患者刺激后的全唾液的蛋白质组成、唾液酸含量以及钙和磷的含量，与17名健康受试者的对照唾液样本进行了比较。在原发性和继发性干燥综合征中，白蛋白、胱抑素C、胱抑素S、总IgA和总蛋白的绝对浓度均显著升高，但淀粉酶除外。然而，干燥综合征患者中总蛋白、白蛋白、淀粉酶和IgA的每分钟分泌量却有所下降。这些结果表明，唾液防御因子分泌量的减少，而非其绝对浓度，可能与干燥综合征患者出现的口腔健康问题有关。
