Ojima K, Abiru H, Fukui Y
Department of Legal Medicine, Kyoto University Faculty of Medicine, Japan.
Int J Dev Neurosci. 1996 Aug;14(5):649-54. doi: 10.1016/0736-5748(95)00105-0.
We investigated the effects of cocaine on the corpus callosum, the nerve fibre bundle that connects the bilateral cerebral hemispheres. Our experiments in rats confirmed that, in the control group, the mid-sagittal area of the corpus callosum in the adult male was significantly larger than this area in the female. Early postnatal exposure to cocaine abolished this sexual dimorphism, that is, cocaine-treated males had a significantly smaller callosal area than the control males. Cocaine induced no significant changes in the weight of the body or brain. There were no significant sex differences in the midline sagittal area of the anterior commissure, and no apparent effects of cocaine exposure were determined in this structure. These findings suggest that early postnatal exposure to cocaine abolishes the sexual differentiation of the corpus callosum in male rats.
我们研究了可卡因对胼胝体的影响，胼胝体是连接双侧大脑半球的神经纤维束。我们在大鼠身上进行的实验证实，在对照组中，成年雄性大鼠胼胝体的矢状中线面积显著大于雌性大鼠的该区域面积。出生后早期接触可卡因消除了这种性别差异，也就是说，经可卡因处理的雄性大鼠胼胝体面积显著小于对照雄性大鼠。可卡因对身体或大脑重量没有显著影响。前连合的矢状中线面积没有显著的性别差异，并且未确定可卡因暴露对该结构有明显影响。这些发现表明，出生后早期接触可卡因会消除雄性大鼠胼胝体的性别分化。
