Ojima K, Abiru H, Matsumoto H, Fukui Y
Department of Legal Medicine, Kyoto University Faculty of Medicine, Japan.
Reprod Toxicol. 1996 May-Jun;10(3):221-5. doi: 10.1016/0890-6238(96)00025-1.
We investigated the effects of cocaine on the development of the corpus callosum in rats. From postnatal days 1 (P1) to 10 (birth = P0), cocaine (10 mg/kg) was subcutaneously injected in the pups, and saline, at the same volume, was administered to control pups. The animals were sacrificed at 110 days of age and a midsagittal section of the callosum was obtained. Morphometric measurement of the corpus callosum was performed in this section. In the control group, but not in the cocaine group, males had larger callosa than females. The cocaine treatment significantly decreased the total callosal area in male rats. These findings indicate that early postnatal cocaine abolishes the sexual differentiation of the corpus callosum.
我们研究了可卡因对大鼠胼胝体发育的影响。从出生后第1天（P1）到第10天（出生 = P0），给幼崽皮下注射可卡因（10毫克/千克），给对照幼崽注射相同体积的生理盐水。在动物110日龄时将其处死，并获取胼胝体的矢状面中部切片。对该切片进行胼胝体的形态测量。在对照组而非可卡因组中，雄性的胼胝体比雌性大。可卡因处理显著降低了雄性大鼠胼胝体的总面积。这些发现表明，出生后早期接触可卡因会消除胼胝体的性别分化。
