Guidetti D, Bondavalli M, Sabadini R, Marcello N, Vinceti M, Cavalletti S, Marbini A, Gemignani F, Colombo A, Ferrari A, Vivoli G, Solimè F
Neurological Division, Santa Maria Nuova Hospital, Reggio Emilia, Italy.
Neuroepidemiology. 1996;15(6):301-12. doi: 10.1159/000109920.
We carried out a retrospective incidence, prevalence and mortality survey of amyotrophic lateral sclerosis (ALS) in the province of Reggio Emilia, northern Italy. Based on 79 patients, the mean incidence per year for the period 1980 through 1992 was 1.5 cases per 100,000. On December 31st, 1992, the prevalence rate was 5.4 per 100,000. In the 10-year period of 1983-1992 the average mortality rate was 1.3 per 100,000 per year. The average age at onset was 61.3 +/- 10.2, the average survival period thereafter was 26.3 months +/- 17.7; 27.3 +/- 17.6 for classic ALS, 19.5 +/- 8.4 for progressive bulbar palsy and 36.3 +/- 41.4 for pseudopolyneuritic ALS. The incidence rate, recorded in public health district No.12, an area with documented lead pollution since the 1970s, was standardized to the sex and age of the population of the province. Its incidence and prevalence rate were comparable to the rates found in the remaining area of the province.
我们对意大利北部雷焦艾米利亚省的肌萎缩侧索硬化症（ALS）进行了一项回顾性发病率、患病率和死亡率调查。基于79名患者，1980年至1992年期间的年平均发病率为每10万人1.5例。1992年12月31日，患病率为每10万人5.4例。在1983 - 1992年的10年期间，平均死亡率为每年每10万人1.3例。发病的平均年龄为61.3±10.2岁，此后的平均生存期为26.3个月±17.7个月；典型ALS为27.3±17.6个月，进行性延髓麻痹为19.5±8.4个月，假多神经炎型ALS为36.3±41.4个月。自20世纪70年代以来有铅污染记录的第12公共卫生区记录的发病率，根据该省人口的性别和年龄进行了标准化。其发病率和患病率与该省其他地区的发病率相当。
