Scarpa M, Colombo A, Panzetti P, Sorgato P
Department of Neurology, University of Modena, Italy.
Acta Neurol Scand. 1988 Jun;77(6):456-60. doi: 10.1111/j.1600-0404.1988.tb05940.x.
A retrospective study of all admissions to the University of Modena Neurological Department from 1976-1986; 51 cases of amyotrophic lateral sclerosis (ALS) were found. ALS mean annual incidence was 0.78/100,000 inhabitants, while prevalence was 2.35/100,000. Mean age at onset was 61.43 years, mean and median duration of illness were, respectively, 28.83 and 24.5 months, and survival at 5 years post-onset was 24.4%. A tendency to higher incidence and prevalence of ALS in the ceramic district, when compared with those of the rest of the province was found. However, the small number of cases did not allow any conclusive statistical correlation between environmental exposure to lead and frequency of ALS.
对1976年至1986年期间摩德纳大学神经科所有住院病例进行的回顾性研究；发现51例肌萎缩侧索硬化症（ALS）患者。ALS的年平均发病率为每10万居民0.78例，患病率为每10万居民2.35例。发病时的平均年龄为61.43岁，疾病的平均和中位持续时间分别为28.83个月和24.5个月，发病后5年的生存率为24.4%。与该省其他地区相比，发现陶瓷产区的ALS发病率和患病率有升高趋势。然而，病例数量较少，无法确定环境铅暴露与ALS发病率之间的确切统计相关性。
