小鼠9号染色体与β-CCM诱导的癫痫发作有关。
Mouse chromosome 9 involvement in beta-CCM-induced seizures.
作者信息
Clément Y, Martin B, Venault P, Chapouthier G
机构信息
Personnalité et Conduites Adaptatives, URA CNRS 1957, Université Paris VI, Hôpital Pitié-Salpêtrière, Paris, France.
出版信息
Neuroreport. 1996 Sep 2;7(13):2226-30.
PMID:8930994
Abstract
Analysis of beta-CCM induced seizures in three inbred strains of mice, ABP/Le, C57BL/6J and C57BL/6ByJ, and their F1s and F2s progeny, allowed identification of a putative seizure susceptibility controlling locus on chromosome 9 near the short-ear locus. The involvement of a gene in the medial segment of this chromosome in both seizure activity and GABA-controlled behaviour is discussed.
摘要
对三种近交系小鼠ABP/Le、C57BL/6J和C57BL/6ByJ及其F1和F2后代中β-CCM诱发癫痫发作的分析，使得在9号染色体上靠近短耳基因座处鉴定出一个假定的癫痫易感性控制基因座。本文讨论了该染色体中段的一个基因在癫痫发作活动和GABA控制行为中的作用。
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