Ventura V, Mauloni M, Mura M, Paltrinieri F, de Aloysio D
Department of Obstetrics and Gynaecology, University of Bologna, Italy.
Osteoporos Int. 1996;6(5):368-75. doi: 10.1007/BF01623010.
We evaluated the bone tissue modifications which occur in pre-, peri- and postmenopausal women by means of an ultrasound (US) device which measures US propagation velocity in the distal metaphysis of the proximal phalanxes of the hand. Before starting the study, two operators assessed the in vivo short-term precision of the device in 12 volunteers, each measured 10 times (5 times by each operator). Then the US velocity in the dominant (DO) and non-dominant (ND) hand was measured in 228 women to evaluate whether there was a difference between US values measured at these sites. Finally, another selected group of 417 healthy pre-, peri- and postmenopausal women, aged from 40 to 65 years, was studied to evaluate the physiological climacteric changes in the US parameter measured: amplitude-dependent speed of sound (AD-SoS). In the 12 volunteers, intra- and inter-observer short-term precision (CV) was 0.4% (for both the operators) and 1.0%, respectively. DO and ND hand AD-SoS values (2074.1 +/- 63.8 m/s and 2077.1 +/- 65.5 m/s, respectively) proved to be highly correlated (r = 0.96, p < 0.0001) in the 228 women studied. AD-SoS distribution (417 subjects) was correlated with age, climacteric condition (premenopause with regular or irregular cycles and natural postmenopause) and body mass index (BMI). In premenopause (253 subjects) the US velocity was higher among women with regular cycles (2107.2 +/- 48.5 m/s) than among those with irregular cycles (2074.7 +/- 44.1 m/s) (p < 0.0001). In postmenopause (164 subjects) an inverse correlation between AD-SoS and the time elapsed since menopause was found (r = -0.42, p < 0.0001). Furthermore, age and BMI were shown to be inversely related to AD-SoS (r = -0.47, p < 0.0001 and r = -0.30, p < 0.0001, respectively) when evaluated in the whole study group. The results obtained confirm that US transmission at the phalanxes is sensitive to pre-, peri- and postmenopausal bone changes. Further studies are needed to evaluate its ability to predict osteoporotic fracture risk.
我们通过一种超声（US）设备评估了绝经前、围绝经期和绝经后女性发生的骨组织改变，该设备可测量手部近端指骨远端干骺端的超声传播速度。在开始研究之前，两名操作人员评估了该设备在12名志愿者体内的短期精度，每人测量10次（每位操作人员各测量5次）。然后，测量了228名女性优势手（DO）和非优势手（ND）的超声速度，以评估这些部位测量的超声值之间是否存在差异。最后，对另一组选定的417名年龄在40至65岁之间的健康绝经前、围绝经期和绝经后女性进行了研究，以评估所测量的超声参数——振幅依赖声速（AD-SoS）的生理性更年期变化。在12名志愿者中，观察者内和观察者间的短期精度（CV）分别为0.4%（两名操作人员均如此）和1.0%。在228名研究女性中，优势手和非优势手的AD-SoS值（分别为2074.1±63.8米/秒和2077.1±65.5米/秒）显示高度相关（r = 0.96，p < 0.0001）。AD-SoS分布（417名受试者）与年龄、更年期状态（月经周期规律或不规律的绝经前以及自然绝经后）和体重指数（BMI）相关。在绝经前（253名受试者），月经周期规律的女性（2107.2±48.5米/秒）的超声速度高于月经周期不规律的女性（2074.7±44.1米/秒）（p < 0.0001）。在绝经后（164名受试者），发现AD-SoS与绝经后经过的时间呈负相关（r = -0.42，p < 0.0001）。此外，在整个研究组中评估时，年龄和BMI与AD-SoS呈负相关（分别为r = -0.47，p < 0.0001和r = -0.30，p < 0.0001）。获得的结果证实，指骨处的超声传播对绝经前、围绝经期和绝经后的骨骼变化敏感。需要进一步研究以评估其预测骨质疏松性骨折风险的能力。
