Rico H, Revilla M, Villa L F, Alvarez de Buergo M
Department of Medicine, Principe de Asturias Hospital, Alcalá de Henares University, Madrid, Spain.
Osteoporos Int. 1993 May;3(3):154-9. doi: 10.1007/BF01623277.
Total body bone mineral content (TBBMC), total body bone mineral density (TBBMD) and regional bone mineral content (BMC) and density (BMD) were assessed by dual-energy X-ray absorptiometry (DXA) in 429 normal women aged 15-83 years, of whom 242 were premenopausal and 187 postmenopausal. The population was divided into 5-year age groups. In the premenopausal women no changes in TBBMC, TBBMD or regional BMC and BMD were observed with age, and TBBMC and TBBMD values correlated well with body weight (p < 0.001). Postmenopausal women showed an overall reduction in bone mass (p < 0.001), more marked at the axial level than peripherally (1.6% vs. 0.8%/year). The values of TBBMC and TBBMD correlated well with chronological age, time since the onset of menopause and body weight (p < 0.001). In these women age did not correlate with body weight, which suggests that postmenopausal bone mass loss depends more on chronological age and time since the onset of menopause than on other variables. The stability observed in bone mass values from ages 15-19 to menopause highlights the importance of stimulating the acquisition of an appropriate peak bone mass in women before adolescence begins.
采用双能X线吸收法（DXA）对429名年龄在15至83岁的正常女性进行全身骨矿物质含量（TBBMC）、全身骨矿物质密度（TBBMD）以及局部骨矿物质含量（BMC）和密度（BMD）的评估，其中242名处于绝经前，187名处于绝经后。将研究人群按5岁年龄组进行划分。在绝经前女性中，未观察到TBBMC、TBBMD或局部BMC和BMD随年龄的变化，且TBBMC和TBBMD值与体重显著相关（p < 0.001）。绝经后女性的骨量总体减少（p < 0.001），轴向部位比外周部位更明显（每年分别减少1.6%和0.8%）。TBBMC和TBBMD值与实际年龄、绝经开始后的时间以及体重显著相关（p < 0.001）。在这些女性中，年龄与体重不相关，这表明绝经后骨量丢失更多地取决于实际年龄和绝经开始后的时间，而非其他变量。15至19岁至绝经期间骨量值的稳定性突出了在青春期开始前促进女性获得适当峰值骨量的重要性。
