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视网膜神经节细胞密度影响中央凹发育的证据。

Evidence that retinal ganglion cell density affects foveal development.

作者信息

Leventhal A G

机构信息

Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City 84132, USA.

出版信息

Perspect Dev Neurobiol. 1996;3(3):203-11.

PMID:8931094
Abstract

The monkey's foveola normally contains significant numbers of retinal ganglion cells. The somata of foveola cells are larger than those of other cells in the central retina. Their dendritic fields are up to 50 times larger in area than those of nearby cells in the foveal slope. Experimentally induced reductions in the number of ganglion cells in central retina results in alterations in the size and distribution of cells within the foveola. In these animals the foveola is abnormally small and contains an abnormally large number of cells having smaller than normal cell bodies and dendritic fields. These studies indicate that the formation of the foveola as well as the development of the morphology of cells within the foveola and foveal slope depend during development on high densities of retinal ganglion cells within the central retina.

摘要

猴的中央小凹通常含有大量视网膜神经节细胞。中央小凹细胞的胞体比中央视网膜其他细胞的胞体更大。它们的树突野面积比中央凹斜坡附近细胞的树突野面积大50倍。实验诱导中央视网膜神经节细胞数量减少会导致中央小凹内细胞大小和分布的改变。在这些动物中,中央小凹异常小,并且含有大量细胞,这些细胞的胞体和树突野比正常的小。这些研究表明,中央小凹的形成以及中央小凹和中央凹斜坡内细胞形态的发育在发育过程中依赖于中央视网膜内高密度的视网膜神经节细胞。

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Evidence that retinal ganglion cell density affects foveal development.视网膜神经节细胞密度影响中央凹发育的证据。
Perspect Dev Neurobiol. 1996;3(3):203-11.
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