Ohnishi H, Nishihara K, Tamae K, Mitsuyama S, Abe R, Toyoshima S, Abe E
Department of Surgery, Kitakyushu Municipal Medical Center, Japan.
Surg Today. 1996;26(11):929-32. doi: 10.1007/BF00311799.
Granular cell tumors (GCT) are rare neoplasms, and only 173 cases of benign GCT of the breast have been documented. We report herein the cases of two patients with this tumor and discuss the methods of diagnosis and treatment. The first patient was a 60-year-old woman who presented with a firm ill-defined mass in her left breast. Mammography showed a dense shadow with spicula and skin thickness, and ultrasonography revealed a hypoechoic mass with an irregular border. Radical mastectomy was performed under the wrong preoperative diagnosis of breast cancer. The second patient was a 31-year-old woman who presented with an elastic-hard mass in her left breast. Mammography showed a well-demarcated dense mass, and ultrasonography revealed a well-defined hypoechoic mass with a large depth-width ratio. Fine-needle aspiration cytology (FNAC) showed a large number of histiocytic cells with abundant granular cytoplasm. An excisional biopsy was performed, and histological examination confirmed a diagnosis of GCT. GCT is benign, but often misdiagnosed as breast cancer both clinically and radiologically. Therefore, histological examination is essential for making a correct diagnosis, while FNAC is also useful. Local resection is still the treatment of choice, and surgeons should do their utmost to avoid performing needless radical mastectomy.
颗粒细胞瘤（GCT）是一种罕见的肿瘤，仅有173例乳腺良性GCT的病例被记录在案。我们在此报告两例该肿瘤患者的病例，并讨论其诊断和治疗方法。首例患者为一名60岁女性，其左乳出现一个边界不清的实性肿块。乳房X线摄影显示有一个伴有毛刺和皮肤增厚的致密阴影，超声检查显示一个边界不规则的低回声肿块。在术前误诊为乳腺癌的情况下进行了根治性乳房切除术。第二例患者是一名31岁女性，其左乳出现一个质地硬如橡皮的肿块。乳房X线摄影显示一个边界清晰的致密肿块，超声检查显示一个边界清晰、深宽比大的低回声肿块。细针穿刺细胞学检查（FNAC）显示大量具有丰富颗粒状细胞质的组织细胞。进行了切除活检，组织学检查确诊为GCT。GCT是良性的，但在临床和影像学上常被误诊为乳腺癌。因此，组织学检查对于做出正确诊断至关重要，而FNAC也很有用。局部切除仍然是首选的治疗方法，外科医生应尽最大努力避免进行不必要的根治性乳房切除术。
