Gonschior P, Gerheuser F, Fleuchaus M, Huehns T Y, Goetz A E, Welsch U, Sroka R, Dellian M, Lehr H A, Höfling B
Medical Department I, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany.
Photochem Photobiol. 1996 Nov;64(5):758-63. doi: 10.1111/j.1751-1097.1996.tb01831.x.
Local photodynamic therapy may have potential in preventing myointimal hyperplasia after angioplasty. In this study, the effect of photodynamic therapy was evaluated in an experimental model of restenosis. Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries. Animals were randomly allocated to four groups: group 1, unidirectional injury only; group 2, injury followed by local delivery of photosensitizer; group 3, injury followed by local exposure to monochromatic light; and group 4, where injury was followed by local drug delivery of photosensitizer and subsequent exposure to light (photodynamic therapy). Seven, 14 or 21 days after treatment, all experimental vessels were excised, fixed and processed for histology. An inflammatory and myoproliferative response was observed after injury in vessels from groups 1, 2 and 3. In group 4, after injury followed by photodynamic therapy, the myoproliferative response was significantly reduced. Thus, in this study, tissue hyperplasia after unidirectional injury was effectively suppressed by photodynamic therapy.
局部光动力疗法在预防血管成形术后肌内膜增生方面可能具有潜力。在本研究中，在再狭窄的实验模型中评估了光动力疗法的效果。使用定向旋切导管对猪动脉进行标准化的单向动脉损伤。将动物随机分为四组：第1组，仅单向损伤；第2组，损伤后局部递送光敏剂；第3组，损伤后局部暴露于单色光；第4组，损伤后局部递送光敏剂并随后暴露于光（光动力疗法）。治疗后7、14或21天，切除所有实验血管，固定并进行组织学处理。在第1、2和3组的血管损伤后观察到炎症和肌增殖反应。在第4组中，损伤后进行光动力疗法，肌增殖反应明显降低。因此，在本研究中，光动力疗法有效抑制了单向损伤后的组织增生。
