Kothari M J, Rutkove S B, Logigian E L, Shefner J M
Division of Neurology, College of Medicine, Pennsylvania State University, Hershey 17033, USA.
Arch Phys Med Rehabil. 1996 Nov;77(11):1186-8. doi: 10.1016/s0003-9993(96)90146-x.
To determine the incidence of entrapment neuropathy in patients with amyotrophic lateral sclerosis (ALS). Although it is well known that patients with motor neuron disease may have coexisting focal neuropathies, their prevalence has not been previously determined.
Electrophysiologic studies (EMG/NCS) were reviewed from 126 patients with ALS seen at a university-affiliated hospital from 1991 to 1994. Every patient had an EMG/ NCS consistent with motor neuron disease (i.e., active and chronic denervation in at least 3 body regions).
Forty-three percent (54 patients) had evidence of a neuropathy. Abnormalities included median neuropathy at the wrist in 15 (12%), ulnar neuropathy at the elbow in 18 (14%), nonlocalized ulnar neuropathy in 10 (8%), and peroneal neuropathy at the fibular head in 2 (2%). Furthermore, 9 patients (7%) had a superimposed polyneuropathy. Of these 54 patients, 7 (13%) had clinical symptoms of their neuropathy.
Coexistent focal or generalized neuropathies in ALS are not uncommon. Careful attention to these abnormalities may decrease morbidity in these patients.
确定肌萎缩侧索硬化症（ALS）患者中卡压性神经病的发病率。虽然运动神经元病患者可能并存局灶性神经病，但其患病率此前尚未确定。
回顾了1991年至1994年在一所大学附属医院就诊的126例ALS患者的电生理研究（肌电图/神经传导速度测定）。每位患者的肌电图/神经传导速度测定结果均符合运动神经元病（即至少3个身体部位存在活动性和慢性失神经支配）。
43%（54例）患者有神经病证据。异常情况包括腕部正中神经病变15例（12%）、肘部尺神经病变18例（14%）、非局限性尺神经病变10例（8%）以及腓骨头处腓总神经病变2例（2%）。此外，9例患者（7%）合并有多发性神经病。在这54例患者中，7例（13%）有神经病的临床症状。
ALS患者并存局灶性或全身性神经病并不罕见。对这些异常情况予以密切关注可能会降低这些患者的发病率。
