Koepp M J, Richardson M P, Brooks D J, Poline J B, Van Paesschen W, Friston K J, Duncan J S
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Brain. 1996 Oct;119 ( Pt 5):1677-87. doi: 10.1093/brain/119.5.1677.
We objectively delineated the extent of abnormalities in central benzodiazepine receptor (cBZR) binding using [11C]flumazenil (FMZ)-PET and high resolution volumetric MRI in 12 patients with mesial temporal lobe epilepsy (mTLE) associated with unilateral hippocampal sclerosis, who underwent presurgical evaluation and subsequent temporal lobe surgery. We compared parametric 3D-images of regional cerebral [11C]FMZ volume of distribution (Vd) obtained from individuals and groups of patients with [11C]FMZ-Vd from a group of 17 healthy controls using statistical parametric mapping (SPM). The [12C]FMZ-Vd was significantly reduced (P < 0.001) in the affected hippocampus in the group of 12 patients with unilateral hippocampal sclerosis. Analysis of individual patients reflected the group finding and there was no significant abnormality of cBZR binding outside the hippocampus in any patient. We conclude that SPM is an useful objective method for detecting changes in regional cerebral [11C]FMZ binding and that in patients with mTLE and unilateral hippocampal sclerosis reduction of cBZR binding is restricted to the area of hippocampal sclerosis with no abnormalities being detected in the temporal neocortex or elsewhere in the neocortex.
我们采用[11C]氟马西尼（FMZ）-PET和高分辨率容积MRI，对12例伴有单侧海马硬化的内侧颞叶癫痫（mTLE）患者进行术前评估及后续颞叶手术，客观地描绘了中枢苯二氮䓬受体（cBZR）结合异常的范围。我们使用统计参数映射（SPM），将从个体和患者组获得的区域脑[11C]FMZ分布容积（Vd）的参数化三维图像，与一组17名健康对照者的[11C]FMZ-Vd进行比较。在12例单侧海马硬化患者组中，患侧海马的[12C]FMZ-Vd显著降低（P < 0.001）。对个体患者的分析反映了组内结果，且任何患者海马以外的cBZR结合均无明显异常。我们得出结论，SPM是检测区域脑[11C]FMZ结合变化的一种有用的客观方法，并且在mTLE和单侧海马硬化患者中，cBZR结合的减少仅限于海马硬化区域，在颞叶新皮质或新皮质其他部位未检测到异常。
