库拉索菌素A和B，由拟青霉属FO-3684菌株产生的新型蛋白质法尼基转移酶抑制剂。II. 结构解析与全合成。
Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.
作者信息
Uchida R, Shiomi K, Sunazuka T, Inokoshi J, Nishizawa A, Hirose T, Tanaka H, Iwai Y, Omura S
机构信息
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1996 Sep;49(9):886-9. doi: 10.7164/antibiotics.49.886.
PMID:8931722
Abstract
The structures of new protein farnesyltransferase inhibitors, kurasoins A and B, were elucidated by NMR study. Kurasoins A and B are acyloin compounds having in common a 3-hydroxy-1-phenyl-2-butanone moiety, to which p-hydroxyphenyl and 3-indolyl moieties respectively, are connected at C-4. The structures were confirmed by total synthesis.
摘要
通过核磁共振研究阐明了新型蛋白质法尼基转移酶抑制剂库拉索因A和B的结构。库拉索因A和B是偶姻化合物，它们共同具有一个3-羟基-1-苯基-2-丁酮部分，在C-4位分别连接有对羟基苯基和3-吲哚基部分。通过全合成确认了其结构。
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