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库拉索菌素A和B，由拟青霉属FO-3684菌株产生的新型蛋白质法尼基转移酶抑制剂。II. 结构解析与全合成。

Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.

作者信息

Uchida R, Shiomi K, Sunazuka T, Inokoshi J, Nishizawa A, Hirose T, Tanaka H, Iwai Y, Omura S

机构信息

Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1996 Sep;49(9):886-9. doi: 10.7164/antibiotics.49.886.

DOI:10.7164/antibiotics.49.886
PMID:8931722
Abstract

The structures of new protein farnesyltransferase inhibitors, kurasoins A and B, were elucidated by NMR study. Kurasoins A and B are acyloin compounds having in common a 3-hydroxy-1-phenyl-2-butanone moiety, to which p-hydroxyphenyl and 3-indolyl moieties respectively, are connected at C-4. The structures were confirmed by total synthesis.

摘要

通过核磁共振研究阐明了新型蛋白质法尼基转移酶抑制剂库拉索因A和B的结构。库拉索因A和B是偶姻化合物，它们共同具有一个3-羟基-1-苯基-2-丁酮部分，在C-4位分别连接有对羟基苯基和3-吲哚基部分。通过全合成确认了其结构。

相似文献

1
Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.库拉索菌素A和B，由拟青霉属FO-3684菌株产生的新型蛋白质法尼基转移酶抑制剂。II. 结构解析与全合成。
J Antibiot (Tokyo). 1996 Sep;49(9):886-9. doi: 10.7164/antibiotics.49.886.
2
Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. I. Producing strain, fermentation, isolation, and biological activities.库拉索菌素A和B，由拟青霉属菌株FO-3684产生的新型蛋白质法尼基转移酶抑制剂。I. 产生菌株、发酵、分离及生物活性。
J Antibiot (Tokyo). 1996 Sep;49(9):932-4. doi: 10.7164/antibiotics.49.932.
3
Syntheses and absolute structures of novel protein farnesyltransferase inhibitors, kurasoins A and B.新型蛋白质法尼基转移酶抑制剂库拉索因A和B的合成及绝对结构
J Antibiot (Tokyo). 1997 May;50(5):453-5. doi: 10.7164/antibiotics.50.453.
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Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities.安曲霉素A-C，由青霉菌FO-3929产生的新型蛋白法尼基转移酶抑制剂。I. 产生菌、发酵、分离及生物活性。
J Antibiot (Tokyo). 1996 May;49(5):414-7. doi: 10.7164/antibiotics.49.414.
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Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure elucidation and biosynthesis.安曲汀A-C，由青霉菌FO-3929产生的新型蛋白质法尼基转移酶抑制剂。II. 结构解析与生物合成。
J Antibiot (Tokyo). 1996 May;49(5):418-24. doi: 10.7164/antibiotics.49.418.
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Andrastin D, novel protein farnesyltransferase inhibitor produced by Penicillium sp. FO-3929.
J Antibiot (Tokyo). 1996 Dec;49(12):1278-80. doi: 10.7164/antibiotics.49.1278.
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