Vachálková A, Bransová J, Brtko J, Uher M, Novotný L
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.
Neoplasma. 1996;43(4):265-9.
Polarographic properties of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one] and 10 of their synthetic derivatives were investigated. It was shown that these compounds are reduced in anhydrous conditions, usually in one two-electron step or in two one-electron steps. The presence of some substituents may change the course of reduction process. The polarography of these compounds in the presence of alpha-lipoic acid showed the kojic acid analog-alpha-lipoic acid complex formation. The determined potential carcinogenic activity of these compounds expressed as a parameter tg alpha is not substantial.
研究了曲酸[5-羟基-2-(羟甲基)-4H-吡喃-4-酮]及其10种合成衍生物的极谱性质。结果表明，这些化合物在无水条件下被还原，通常是通过一步双电子过程或两步单电子过程。某些取代基的存在可能会改变还原过程。这些化合物在α-硫辛酸存在下的极谱分析表明形成了曲酸类似物-α-硫辛酸复合物。这些化合物以参数tgα表示的潜在致癌活性测定结果并不显著。
