具有抗白血病活性的5-氮杂核苷的极谱还原和致癌指数tgα
Polarographic reduction and carcinogenic index tg alpha of 5-aza nucleosides possessing antileukemic activity.
作者信息
Vachálková A, Novotný L, Pískala A
机构信息
Department of Experimental Therapy, Slovak Academy of Sciences, Bratislava.
出版信息
Neoplasma. 1993;40(5):289-92.
PMID:7505887
Abstract
Polarographic behavior of arabinosyl-5-azacytosine (ara-AC) and 5-azacytidine in anhydrous dimethylformamide and in Britton Robinson buffer is described. 5-Azacytidine and ara-AC underwent two-electron reduction under the polarographic conditions used. Carcinogenic index tg alpha estimated in the presence of alpha-lipoic acid was 0.295 for 5-azacytidine and 0.275 for ara-AC.
摘要
描述了阿拉伯糖基-5-氮杂胞嘧啶（ara-AC）和5-氮杂胞苷在无水二甲基甲酰胺及布里顿-罗宾逊缓冲液中的极谱行为。在所用极谱条件下，5-氮杂胞苷和ara-AC经历了双电子还原。在α-硫辛酸存在下估算的致癌指数tgα，5-氮杂胞苷为0.295，ara-AC为0.275。
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