Doyle P
Neonatal Netw. 1996 Sep;15(6):35-40.
The use of corticosteroids as a treatment for chronic lung disease is increasing in newborn intensive care units. The anti-inflammatory mechanism of steroids suppresses the pulmonary inflammatory response, leading to improved pulmonary compliance and often a successful extubation. However, side effects, including sepsis, hypertension, glucosuria, and heme positive stools, have been reported. Caregivers must appreciate the multisystem biochemical effects of corticosteroids and anticipate the potential side effects when administering this medication. The article reviews the biochemical processes of dexamethasone, a synthetic corticosteroid, and presents a case study of an infant receiving dexamethasone. A question-and-answer format is interpolated throughout the case study and is intended to challenge the reader's knowledge of the pathophysiology of chronic lung disease and the biochemical actions of corticosteroids. Implications for nursing assessment and management of infants receiving this medication are reviewed.
在新生儿重症监护病房中，使用皮质类固醇治疗慢性肺病的情况日益增多。类固醇的抗炎机制可抑制肺部炎症反应，从而改善肺顺应性，并常常能成功撤机。然而，已有报道称其存在副作用，包括败血症、高血压、糖尿和大便潜血阳性。护理人员必须了解皮质类固醇的多系统生化作用，并在使用这种药物时预见到潜在的副作用。本文回顾了合成皮质类固醇地塞米松的生化过程，并呈现了一个接受地塞米松治疗的婴儿的案例研究。在整个案例研究中穿插了问答形式，旨在考验读者对慢性肺病病理生理学和皮质类固醇生化作用的了解。文中还回顾了对接受这种药物治疗的婴儿进行护理评估和管理的相关内容。
