Ross U H, Reinhardt M J, Reuland P
Department of Oto-Rhino-Laryngology, University of Freiburg, Germany.
Eur Arch Otorhinolaryngol. 1996;253(1-2):17-20. doi: 10.1007/BF00176696.
To determine the diagnostic value of tympanocochlear scintigraphy (TCS), which is still used for the visualization of alterations of labyrinthine bone metabolism due to active otosclerosis, resolution and detection limits were examined in a normal human temporal bone model. After incubation in technetium-99m-labeled diphosphonate solution, scintigraphic imaging showed the zygomatic process and the clivus as landmarks for fine structures of the petrous bone. For further differentiation, labyrinthine fine structures were marked with radioactive tracers of 0.5-1 mm2 each. High-resolution scintigraphic imaging gave two-point discrimination for structures as small as 2.5 mm apart. Localization of the activity patterns was improved by correlating imaging with X-ray photographs or by superimposition with masks of the prepared temporal bones drawn from the X-rays. The correlation of scintigraphic findings with X-ray photographs was found to provide a powerful method for improving the accuracy of localizing temporal bone metabolic changes as it is applicable clinically for studying the occurrence of small active otosclerotic foci.
为了确定仍用于可视化由于活跃性耳硬化症导致的迷路骨代谢改变的鼓室耳蜗闪烁扫描术（TCS）的诊断价值，在正常人类颞骨模型中检查了分辨率和检测限。在99m锝标记的二膦酸盐溶液中孵育后，闪烁扫描成像显示颧骨突和斜坡作为岩骨精细结构的标志。为了进一步区分，用每块面积为0.5 - 1平方毫米的放射性示踪剂标记迷路精细结构。高分辨率闪烁扫描成像对相距仅2.5毫米的结构给出了两点辨别。通过将成像与X线照片相关联或与从X线片绘制的制备好的颞骨模板叠加，改善了活性模式的定位。发现闪烁扫描结果与X线照片的相关性为提高颞骨代谢变化定位的准确性提供了一种有力方法，因为它可临床应用于研究小的活跃性耳硬化病灶的发生情况。
