Cardile V, Mascarucci P, De Simoni M G, Jiang X, Bindoni M
Institute of Human Physiology, Faculty of Medicine, University of Catania, Italy.
Cytokine. 1996 Sep;8(9):698-701. doi: 10.1006/cyto.1996.0092.
The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the greatest effect at the dose of 2 micrograms/ml. PAF had no effect. The non-metabolizable CPAF was less effective than ET-18-OCH3 and showed the greatest release of IL-6 at the dose of 1 microgram/ml. Ether lipid ET-18-OCH3 has a thymotrophic effect as has also been demonstrated by other results obtained in our previous work.
研究了醚脂1-O-十八烷基-2-O-甲氧基-rac-甘油-3-磷酸胆碱（ET-18-OCH3）、血小板活化因子（PAF）和氨甲酰活化因子（CPAF）对体外培养的人胸腺上皮细胞中白细胞介素-6（IL-6）释放的影响。ET-18-OCH3显著增加IL-6的释放，在2微克/毫升的剂量下效果最佳。PAF没有影响。不可代谢的CPAF比ET-18-OCH3效果差，在1微克/毫升的剂量下IL-6释放量最大。醚脂ET-18-OCH3具有促胸腺细胞生长的作用，这也已被我们之前工作中获得的其他结果所证实。
