Meyer M J, Bechtold W E
Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87115, USA.
Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):879-82. doi: 10.1289/ehp.96104s5879.
Covalent protein adducts formed after exposure to xenobiotics may provide readily measurable indicators of these exposures. After adequate characterization of the dose-dependent formation of a specific adduct, the adduct can often be used as a quantitative marker for exposure, DNA adduct formation, or, possibly, risk of disease. By elucidating the structure of an adduct and studying the conditions under which it forms, information about the reactions that lead to its formation can be obtained. Continuing work in this area includes methods to expand the number, types, and levels of chemical exposures that can be studied by covalent adduct formation. In addition to the use of this technology in the field of occupational health, basic research in this area provides insights into metabolic pathways and biochemistry, as well.
接触外源性物质后形成的共价蛋白加合物可能为这些接触提供易于测量的指标。在充分表征特定加合物的剂量依赖性形成后，该加合物通常可作为接触、DNA加合物形成或可能的疾病风险的定量标志物。通过阐明加合物的结构并研究其形成的条件，可以获得有关导致其形成的反应的信息。该领域正在进行的工作包括扩大可通过共价加合物形成进行研究的化学接触的数量、类型和水平的方法。除了在职业健康领域使用这项技术外，该领域的基础研究也为代谢途径和生物化学提供了见解。
