van Sittert N J, Beulink G D, van Vliet E W, van der Waal H
Health, Safety and Environment Division, Shell Internationale Petroleum Maatschappij, The Hague, The Netherlands.
Environ Health Perspect. 1993 Mar;99:217-20. doi: 10.1289/ehp.9399217.
In a study on workers in a chemical plant where ethylene oxide (EtO) is manufactured and partly used for ethylene glycol production, exposure to EtO was monitored during annual periodic health assessments in January 1988, December 1988, and March 1990 by the determination of the level of 2-hydroxyethylvaline (HOEtVal) in hemoglobin. The HOEtVal levels in workers corresponded with the potential EtO exposures. The highest level was found in December 1988, in blood samples collected 1-2 months after a shut-down, maintenance, and start-up program. The range of adduct levels found in the three examinations indicated that average EtO exposures during the 4 months preceding blood sampling were below 0.5 ppm. It was demonstrated that the method allows for the accurate monitoring of low levels of EtO exposure and provides personalized time-integrated exposure data with great discriminative power. In addition, the method may serve to identify unexpected personal exposures, which may lead to targeted exposure control measures.
在一项针对一家生产环氧乙烷（EtO）且部分用于生产乙二醇的化工厂工人的研究中，于1988年1月、1988年12月和1990年3月的年度定期健康评估期间，通过测定血红蛋白中2 - 羟乙基缬氨酸（HOEtVal）的水平来监测EtO暴露情况。工人的HOEtVal水平与潜在的EtO暴露相对应。最高水平出现在1988年12月，是在一次停工、维护和启动程序后1 - 2个月采集的血样中。三次检查中发现的加合物水平范围表明，采血前4个月期间的平均EtO暴露低于0.5 ppm。结果表明，该方法能够准确监测低水平的EtO暴露，并提供具有强大鉴别力的个性化时间积分暴露数据。此外，该方法可用于识别意外的个人暴露情况，这可能会促使采取有针对性的暴露控制措施。
