Haelens A, Wuyts A, Proost P, Struyf S, Opdenakker G, van Damme J
Rega Institute for Medical Research, University of Leuven, Laboratory for Molecular Immunology, Belgium.
Immunobiology. 1996 Oct;195(4-5):499-521. doi: 10.1016/S0171-2985(96)80019-2.
Chemokines are a family of chemotactic cytokines which attract different types of leukocytes. This property, combined with some additional inflammatory and growth-regulatory activities, demonstrate their crucial role in the immune system. Chemokines are low molecular weight proteins and possess a typical positioning of four conserved cysteines. This family is further subdivided in two subfamilies depending on whether the first two cysteines are adjacent or not (CC and CXC chemokines, respectively). The CXC chemokines (including interleukin-8) predominantly attract neutrophils, whereas CC chemokines induce migration of monocytes, as well as other leukocyte cell types. In this article, the general characteristics of chemokines are reviewed. Furthermore, the murine CC chemokines, JE/MCP-1, MCP-3/MARC, MIP-1 alpha, MIP-1 beta, RANTES, TCA3, C10/MRP-1, MRP-2, and eotaxin, are discussed more in detail.
趋化因子是一类趋化性细胞因子，可吸引不同类型的白细胞。这种特性，再加上一些额外的炎症和生长调节活性，证明了它们在免疫系统中的关键作用。趋化因子是低分子量蛋白质，具有四个保守半胱氨酸的典型排列。根据前两个半胱氨酸是否相邻，这个家族进一步细分为两个亚家族（分别为CC趋化因子和CXC趋化因子）。CXC趋化因子（包括白细胞介素-8）主要吸引中性粒细胞，而CC趋化因子则诱导单核细胞以及其他白细胞类型的迁移。本文综述了趋化因子的一般特征。此外，还将更详细地讨论小鼠CC趋化因子JE/MCP-1、MCP-3/MARC、MIP-1α、MIP-1β、RANTES、TCA3、C10/MRP-1、MRP-2和嗜酸性粒细胞趋化因子。
