Teramoto S, Matsuse T, Sudo E, Ohga E, Katayama H, Suzuki M, Ouchi Y, Fukuchi Y
Department of Geriatrics, Faculty of Medicine, University of Tokyo.
Intern Med. 1996 Oct;35(10):772-8. doi: 10.2169/internalmedicine.35.772.
To investigate the long-term effects of the inhaled anticholinergic bronchodilator, oxitropium bromide (OTB), on lung function, exercise capacity, and dyspnea in patients with chronic obstructive pulmonary disease (COPD), spirometry and symptom-limited exercise testing before and 1, 6, and 12 months after the regular use of OTB (600 micrograms/day) were performed in 12 patients with the use of OTB (mean age 69.9 +/- 3.1 years; FEV1/FVC 53.3 +/- 1.6%) as well as in 12 control patients who were not treated with OTB (Mean age 68.8 +/- 2.8 years; FEV1/FVC 52.6 +/- 1.9%). The dyspnea was evaluated by the slope of the regression line between Borg scale and oxygen uptake (Vo2) during exercise (Borg scale slope: BSS). At 1, 6, and 12 months after the start of OTB, the forced expiratory volume in one second (FEV1) and the exercise capacity (maximal Vo2) were greater than the pretreatment values and the dyspnea index (BSS) was significantly improved compared with the pretreatment value, while these parameters slightly worsened in the control patients over one year. In conclusion, the chronic use of an inhaled anticholinergic bronchodilator may provide beneficial improvements in expiratory flow rate, exercise performance, and dyspnea in mild to moderate COPD patients over one year.
为研究吸入性抗胆碱能支气管扩张剂氧托溴铵（OTB）对慢性阻塞性肺疾病（COPD）患者肺功能、运动能力和呼吸困难的长期影响，对12例使用OTB（600微克/天）的患者以及12例未接受OTB治疗的对照患者（平均年龄68.8±2.8岁；FEV1/FVC 52.6±1.9%）进行了常规使用OTB前以及使用后1、6和12个月的肺活量测定和症状限制性运动测试（使用OTB的患者平均年龄69.9±3.1岁；FEV1/FVC 53.3±1.6%）。通过运动期间Borg量表与摄氧量（Vo2）之间回归线的斜率评估呼吸困难（Borg量表斜率：BSS）。在开始使用OTB后的1、6和12个月，一秒用力呼气量（FEV1）和运动能力（最大Vo2）大于治疗前值，与治疗前值相比，呼吸困难指数（BSS）显著改善，而这些参数在对照患者中在一年期间略有恶化。总之，长期使用吸入性抗胆碱能支气管扩张剂可能会使轻至中度COPD患者的呼气流量率、运动表现和呼吸困难在一年中得到有益改善。
