Herzog H
Institut für Medizin, Forschungszentrum Jülich GmbH, Jülich, Deutschland.
Nuklearmedizin. 1996 Oct;35(5):181-5.
The measurement of blood flow in various organs and its visual presentation in parametric images is a major application in nuclear medicine. The purpose of this paper is to summarize the most important nuclear medicine procedures used to quantify regional blood flow. Starting with the first concepts introduced by Fick and later by Kety-Schmidt the basic principles of measuring global and regional cerebral blood are discussed and their relationships are explained. Different applications and modifications realized first in PET- and later in SPECT-studies of the brain and other organs are described. The permeability and the extraction of the different radiopharmaceuticals are considered. Finally some important instrumental implications are compared.
测量各器官中的血流并在参数图像中进行可视化呈现是核医学的一项主要应用。本文旨在总结用于量化局部血流的最重要的核医学程序。从菲克最初提出的概念以及后来凯蒂 - 施密特提出的概念出发，讨论了测量全脑和局部脑血流的基本原理，并解释了它们之间的关系。描述了首先在PET研究以及后来在SPECT研究中实现的针对大脑和其他器官的不同应用及改进。考虑了不同放射性药物的通透性和摄取情况。最后比较了一些重要的仪器方面的影响。
