Witterland A H, Koks C H, Beijnen J H
Dept. of Pharmacy, Slotervaart Hospital/Netherlands Cancer Institute, Amsterdam.
Pharm World Sci. 1996 Oct;18(5):163-70. doi: 10.1007/BF00820727.
Etoposide (Vepesid) is a widely used drug in a variety of neoplasms. To improve the pharmaceutical characteristics of etoposide, etoposide phosphate (Etopophos, Bristol-Myers Squibb) has been developed as a prodrug. Etoposide phosphate is the phosphate ester derivative of etoposide. In comparison to the parent compound, etoposide phosphate is highly soluble in water and can be readily formulated for intravenous use, resulting in higher clinical application. This paper presents information on the pharmaceutical properties and the current status of etoposide phosphate in clinical trials.
依托泊苷（威克）是一种广泛应用于多种肿瘤的药物。为改善依托泊苷的药学特性，磷酸依托泊苷（乐唯，百时美施贵宝公司）已作为前体药物被研发出来。磷酸依托泊苷是依托泊苷的磷酸酯衍生物。与母体化合物相比，磷酸依托泊苷在水中的溶解度很高，并且可以很容易地配制成静脉注射剂，从而具有更高的临床应用价值。本文介绍了磷酸依托泊苷的药学性质以及其在临床试验中的现状。
