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一年内抗肿瘤药物配制中的误差演变与分析

Errors evolution and analysis in antineoplastic drug preparation during one year.

作者信息

Escoms M C, Cabañas M J, Oliveras M, Hidalgo E, Barroso C

机构信息

Pharmacy Service, Hospital Materno-infantil Vall d'Hebron, Barcelona, Spain.

出版信息

Pharm World Sci. 1996 Oct;18(5):178-81. doi: 10.1007/BF00820729.

DOI:10.1007/BF00820729
PMID:8933578
Abstract

We analyzed the errors occurring in the preparation circuit of cytotoxic mixtures of the Centralized Cytotoxic Preparation Unit during one year. Analysis of their evolution meant the investigation of twenty parameters susceptible to error. Each parameter was considered one error opportunity. Error has been defined either by the lack of data or mistake in the controlled parameter. In 4,734 preparations (94,680 parameters) there were 314 errors. The percentage of error per parameter in the first month of study was 0.74; at sixth was 0.34 and the last month was 0.26. Only in four months the day of maximum number of preparations coincided with the day of maximum number of errors. We conclude that the percentage of errors in the preparation process is low with a tendency to decrease and that the number of daily preparations is not the single factor that influences the production of errors.

摘要

我们分析了一年中集中细胞毒性制剂制备单元细胞毒性混合物制备电路中出现的错误。对其演变的分析意味着对20个易出错参数进行调查。每个参数被视为一个错误机会。错误被定义为数据缺失或受控参数错误。在4734次制备(94680个参数)中,有314个错误。研究第一个月每个参数的错误百分比为0.74;第六个月为0.34,最后一个月为0.26。只有四个月的最大制备天数与最大错误天数一致。我们得出结论,制备过程中的错误百分比很低且有下降趋势,并且每日制备数量不是影响错误产生的唯一因素。

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Pharm World Sci. 2005 Aug;27(4):339-43. doi: 10.1007/s11096-005-6034-x.

本文引用的文献

1
ASHP Standard definition of a medication error.美国卫生系统药师协会药物错误的标准定义。
Am J Hosp Pharm. 1982 Feb;39(2):321.
2
Justifying a pediatric critical-care satellite pharmacy by medication-error reporting.通过药物错误报告来论证设立儿科重症监护卫星药房的合理性。
Am J Hosp Pharm. 1986 Feb;43(2):368-71.
3
Fundamentals of medication error research.用药错误研究的基础
Am J Hosp Pharm. 1990 Mar;47(3):555-71.
4
Severity-indexed, incident report-based medication error-reporting program.基于严重程度指数、以事件报告为基础的用药错误报告程序。
Am J Hosp Pharm. 1991 Dec;48(12):2611-6.