Pharmacy Service, Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.
Pharmacy Service, Dr. Balmis General University Hospital, Alicante, Spain.
Front Public Health. 2023 Aug 30;11:1233264. doi: 10.3389/fpubh.2023.1233264. eCollection 2023.
This review wants to highlight the importance of computer programs used to control the steps in the management of dangerous drugs. It must be taken into account that there are phases in the process of handling dangerous medicines in pharmacy services that pose a risk to the healthcare personnel who handle them. Objective: To review the scientific literature to determine what computer programs have been used in the field of hospital pharmacy for the management of dangerous drugs (HDs).
The following electronic databases were searched from inception to July 30, 2021: MEDLINE (via PubMed), Embase, Cochrane Library, Scopus, Web of Science, Latin American and Caribbean Literature in Health Sciences (LILACS) and Medicine in Spanish (MEDES). The following terms were used in the search strategy: "Antineoplastic Agents," "Cytostatic Agents," "Hazardous Substances," "Medical Informatics Applications," "Mobile Applications," "Software," "Software Design," and "Pharmacy Service, Hospital."
A total of 104 studies were retrieved form the databases, and 18 additional studies were obtained by manually searching the reference lists of the included studies and by consulting experts. Once the inclusion and exclusion criteria were applied, 26 studies were ultimately included in this review. Most of the applications described in the included studies were used for the management of antineoplastic drugs. The most commonly controlled stage was electronic prescription; 18 studies and 7 interventions carried out in the preparation stage focused on evaluating the accuracy of chemotherapy preparations.
Antineoplastic electronic prescription software was the most widely implemented software at the hospital level. No software was found to control the entire HD process. Only one of the selected studies measured safety events in workers who handle HDs. Moreover, health personnel were found to be satisfied with the implementation of this type of technology for daily work with these medications. All studies reviewed herein considered patient safety as their final objective. However, none of the studies evaluated the risk of HD exposure among workers.
本综述旨在强调用于控制危险药物管理步骤的计算机程序的重要性。必须考虑到，在药剂科服务中处理危险药物的过程中有一些阶段会对处理这些药物的医护人员构成风险。目的：综述科学文献，以确定在医院药学领域中，有哪些计算机程序已被用于管理危险药物（HDs）。
从建库至 2021 年 7 月 30 日，检索了以下电子数据库：MEDLINE（通过 PubMed）、Embase、Cochrane 图书馆、Scopus、Web of Science、拉丁美洲和加勒比健康科学文献（LILACS）和西班牙语医学文献（MEDES）。在检索策略中使用了以下术语：“抗肿瘤药”、“细胞抑制剂”、“有害物质”、“医学信息学应用”、“移动应用程序”、“软件”、“软件设计”和“医院药学服务”。
从数据库中检索到 104 项研究，通过手动检索纳入研究的参考文献和咨询专家，又获得了 18 项研究。应用纳入和排除标准后，最终纳入了 26 项研究。纳入研究中描述的大多数应用程序都用于管理抗肿瘤药物。最常控制的阶段是电子处方；18 项研究和 7 项干预措施在准备阶段侧重于评估化疗准备的准确性。
抗肿瘤电子处方软件是医院层面应用最广泛的软件。没有发现控制整个 HD 过程的软件。在所选择的研究中，只有一项研究测量了处理 HD 的工作人员的安全事件。此外，卫生人员对实施这种类型的技术以满足他们日常处理这些药物的工作感到满意。所有回顾的研究都将患者安全作为最终目标。然而，没有一项研究评估了工人接触 HD 的风险。
