Brisaert M, Heylen M, Plaizier-Vercammen J
Vrije Universiteit Brussel, Pharmaceutical Institute, Belgium.
Pharm World Sci. 1996 Oct;18(5):182-6. doi: 10.1007/BF00820730.
Erythromycin, an antibiotic commonly used topically in the treatment of acne, is unstable in solution. The stability is influenced by the pH and by the presence of water. The influence of the pH on the stability of erythromycin was investigated even with the use of dimethyl isosorbide as co-solvent instead of water. The addition of zinc was attempted to ameliorate erythromycin stability as suggested in the literature. To investigate these three factors and their interactions, an optimization technique was carried out consisting of a 2(3) factorial analysis and a rotative central composite design. The erythromycin solutions were analysed with an HPLC method. The pH and the concentration of dimethyl isosorbide had a significant influence on the stability of erythromycin but the addition of zinc was not a significant factor. Moreover, there was a significant interaction between the pH and dimethyl isosorbide.
红霉素是一种常用于局部治疗痤疮的抗生素，其在溶液中不稳定。稳定性受pH值和水的存在影响。即使使用二甲基异山梨醇作为共溶剂而非水，也研究了pH值对红霉素稳定性的影响。按照文献建议，尝试添加锌以改善红霉素的稳定性。为研究这三个因素及其相互作用，开展了一项优化技术，包括二水平三因素析因分析和旋转中心复合设计。采用高效液相色谱法分析红霉素溶液。pH值和二甲基异山梨醇浓度对红霉素稳定性有显著影响，但添加锌不是一个显著因素。此外，pH值和二甲基异山梨醇之间存在显著相互作用。
