Aliasgharlou Nasrin, Asghari Sana Farzin, Khoshbakht Saba, Zolfaghari Pezhman, Charkhian Hamed
Department of Chemistry, Faculty of Science, Urmia University, Urmia Iran.
Department of Nanotechnology & Nanomedicine, Hacettepe University, Ankara Turkey.
Turk J Chem. 2020 Dec 16;44(6):1723-1732. doi: 10.3906/kim-2008-23. eCollection 2020.
In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FTIR spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 °C. Further, the developed formulations are stable for 75 days. Also, the antibacterial activity of the developed formulations is investigated against (ATCC® 25923™ and ATCC® 29213™). The obtained data confirm that the application of BA as the crosslinking agent extends the release of EM from EC and PVA polymeric films. The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications.
在本研究中，硼酸（BA）被用作交联剂，以改善两种常用聚合物薄膜——乙基纤维素（EC）和聚乙烯醇（PVA）——在局部给药应用中的特性。所制备的薄膜通过傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）分析进行表征。结果表明，除了BA改性的EC样品外，所制备薄膜的表面均匀且透明。在25℃下放置1小时后，发现EC和PVA薄膜中红霉素（EM）的初始累积释放量分别为0.30和0.36mg/mL，经BA交联后分别降至0.25和0.20mg/mL。此外，所开发的制剂在75天内保持稳定。同时，研究了所开发制剂对（美国典型培养物保藏中心®25923™和美国典型培养物保藏中心®29213™）的抗菌活性。获得的数据证实，使用BA作为交联剂可延长EM从EC和PVA聚合物薄膜中的释放。本研究结果表明，BA交联的EC和PVA薄膜是用于局部控释给药应用的有前景的载体。
