Shimizu M, Katoh M, Imamura M, Modderman J
Safety Study Department, Nihon Bioresearch Inc., Gifu, Japan.
Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 2):S247-53. doi: 10.1006/rtph.1996.0105.
The effect of maternal ingestion of the reduced energy sweetener erythritol was investigated in KBL:JW strain pregnant rabbits. Animals received 1.0, 2.24, or 5.0 g/kg intravenously once daily from Days 6 to 18 of gestation. Maternal effects (auricular edema, and bradypragia) were observed in the high-dose group. No deaths or significant abnormalities occurred in animals given 1.0 or 2.24 g/kg. No effect was observed in the reproductive performance of the dams or in fetal development from ingestion at any of the treatment levels.
在KBL:JW品系怀孕兔子中研究了母体摄入低热量甜味剂赤藓糖醇的影响。在妊娠第6天至18天，动物每天静脉注射1.0、2.24或5.0 g/kg。高剂量组观察到母体效应（耳廓水肿和行动迟缓）。给予1.0或2.24 g/kg的动物未出现死亡或显著异常。在任何治疗水平下，摄入该物质对母兔的生殖性能或胎儿发育均未观察到影响。
