Lee H J, Im J G, Ahn J M, Yeon K M
Department of Diagnostic Radiology, Seoul National University College of Medicine, Korea.
J Comput Assist Tomogr. 1996 Nov-Dec;20(6):979-82. doi: 10.1097/00004728-199611000-00020.
The frequency of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) is higher than that of general population. To evaluate CT findings of lung cancer associated with IPF, we analyzed 32 patients with lung cancer associated with IPF.
We analyzed retrospectively 32 patients with histologically confirmed lung cancer out of 244 consecutive cases diagnosed as IPF by either CT and clinical findings (n = 220) or histologically (n = 24). The patients were 40-85 years old (mean 66 years, M/F = 31/1). Scanning techniques were conventional CT in 24 patients, high-resolution CT (HRCT) in 2 patients, and both conventional CT and HRCT in 6 patients. We analyzed the CT patterns, locations, and histologic types of lung cancer.
The frequency of lung cancer in patients with IPF was 13.1% (32/244). In 17 of 32 patients, the CT findings of lung cancer were ill defined lesions mimicking air-space consolidation. Lung cancer was located mainly in the lower lobes (21/32) and peripheral portion (21/32). Histologically, squamous cell carcinoma was the most common type (18/32).
Typical CT findings of lung cancer were ill defined consolidation-like masses at the peripheral portion where the most advanced fibrosis was located.
特发性肺纤维化（IPF）患者的肺癌发生率高于普通人群。为评估与IPF相关的肺癌的CT表现，我们分析了32例与IPF相关的肺癌患者。
我们回顾性分析了244例经CT和临床检查（n = 220）或组织学检查（n = 24）确诊为IPF的连续病例中32例经组织学证实为肺癌的患者。患者年龄在40 - 85岁之间（平均66岁，男/女 = 31/1）。扫描技术方面，24例患者采用传统CT，2例患者采用高分辨率CT（HRCT），6例患者同时采用传统CT和HRCT。我们分析了肺癌的CT表现模式、位置及组织学类型。
IPF患者中肺癌的发生率为13.1%（32/244）。32例患者中有17例，肺癌的CT表现为边界不清的病灶，类似气腔实变。肺癌主要位于下叶（21/32）及周边部分（21/32）。组织学上，鳞状细胞癌是最常见的类型（18/32）。
肺癌典型的CT表现为位于最严重纤维化所在周边部分边界不清的实变样肿块。
