Bozzao A, Bastianello S, Ferone E, Giugni E, Paolillo A, Bozzao L
Department of Neurological Sciences, University of Rome La Sapienza, Italy.
AJNR Am J Neuroradiol. 1996 Nov-Dec;17(10):1837-42.
To evaluate the use of magnetization transfer and the apparent enhancement of lesions on contrast-enhanced MR images in patients with multiple sclerosis.
Contrast-enhanced T1-weighted spin-echo MR images obtained in 20 patients with relapsing-remitting multiple sclerosis, with and without magnetization transfer, were evaluated to determine the number of enhancing plaques. Comparison was made with unenhanced T1-weighted magnetization transfer images. Contrast-to-noise ratios were obtained for these lesions on both the enhanced and unenhanced magnetization transfer T1-weighted spin-echo MR images.
Ten plaques were considered enhancing only when the enhanced magnetization transfer T1-weighted images (11% or more) were used; however, they were all hyperintense on unenhanced T1-weighted magnetization transfer images. The contrast-to-noise ratios of these lesions were 16.52 for the enhanced images and 15.65 for the unenhanced images. The two values were not statistically different.
In patients with multiple sclerosis, examination with contrast-enhanced magnetization transfer MR images alone may overestimate the number of enhancing plaques.
评估磁化传递技术的应用以及多发性硬化症患者对比增强磁共振成像（MRI）上病变的表观强化情况。
对20例复发缓解型多发性硬化症患者在有和没有磁化传递技术的情况下获得的对比增强T1加权自旋回波MRI图像进行评估，以确定强化斑块的数量。与未增强的T1加权磁化传递图像进行比较。在增强和未增强的磁化传递T1加权自旋回波MRI图像上获取这些病变的对比噪声比。
仅当使用增强的磁化传递T1加权图像（11%或更高）时，才有10个斑块被认为是强化的；然而，它们在未增强的T1加权磁化传递图像上均为高信号。这些病变在增强图像上的对比噪声比为16.52，在未增强图像上为15.65。这两个值在统计学上无差异。
在多发性硬化症患者中，仅使用对比增强磁化传递MRI图像进行检查可能会高估强化斑块的数量。
