Hamberg L M, Hunter G J, Kierstead D, Lo E H, Gilberto González R, Wolf G L
Department of Radiology, Massachusetts General Hospital, Boston, USA.
AJNR Am J Neuroradiol. 1996 Nov-Dec;17(10):1861-9.
To implement a three-dimensional subtraction functional CT technique to permit rapid quantitative mapping of regional cerebral blood volume (CBV).
The 3-D functional CT technique was implemented in a rabbit model using normal and ischemic animals. Two spiral data acquisitions were performed, one before and one during biphasic administration of contrast material. CBV maps were then produced on a voxel-by-voxel basis through the whole brain.
The average normal CBV was 3.3 +/- 0.4 mL/100 g (n = 7), and the regional values were 4.5 +/- 0.6 mL/100 g for cortical gray matter, 2.5 +/- 0.6 mL/100 g for white matter, and 3.7 +/- 0.4 mL/100 g for the basal ganglia. The CBVs in ischemic regions were 1.5 +/- 0.4 mL/100 g, 0.7 +/- 0.7 mL/100 g, and 1.8 +/- 0.9 mL/100 g, respectively.
Subtraction 3-D functional CT is a fast, potentially cost-effective method with which to assess whole-brain CBV. Because the data collected in 3-D functional CT imaging also can be used to produce large-vessel angiograms, its use in a clinical setting can provide a multiparametric study of cerebrovascular abnormalities that encompasses both large and small vessel circulations for patients being examined for stroke.
实施三维减法功能CT技术，以实现对局部脑血容量（CBV）的快速定量映射。
在正常和缺血动物的兔模型中实施三维功能CT技术。进行两次螺旋数据采集，一次在注射造影剂之前，一次在双相注射造影剂期间。然后在全脑范围内逐体素生成CBV图。
正常CBV的平均值为3.3±0.4 mL/100 g（n = 7），皮质灰质的局部值为4.5±0.6 mL/100 g，白质为2.5±0.6 mL/100 g，基底节为3.7±0.4 mL/100 g。缺血区域的CBV分别为1.5±0.4 mL/100 g、0.7±0.7 mL/100 g和1.8±0.9 mL/100 g。
减法三维功能CT是一种快速、可能具有成本效益的评估全脑CBV的方法。由于三维功能CT成像中收集的数据也可用于生成大血管血管造影，因此在临床环境中使用它可为正在接受中风检查的患者提供包括大血管和小血管循环的脑血管异常多参数研究。
