Hamberg L M, Hunter G J, Halpern E F, Hoop B, Gazelle G S, Wolf G L
Department of Radiology, Massachusetts General Hospital, Boston, USA.
AJNR Am J Neuroradiol. 1996 Apr;17(4):639-50.
To implement and validate spiral slip-ring CT for use in cerebrovascular studies.
Continuous data were acquired from an experimental, first-pass, iodine contrast, bolus study by unidirectional X-ray tube rotation, and images were reconstructed at 100-millisecond intervals. Functional maps of cerebral blood volume (CBV) and cerebral blood flow (CBF) were constructed with voxel-by-voxel gamma variate fitting. Reproducibility studies, different injection volumes and sites, and CO2 challenge were applied to verify the technique.
Average absolute cortical gray and white matter and basal ganglia results were reproducible within +/- 0.8 ml/100 g for CBV and +/- 20 ml/100 g per minute for CBF, CBV response to changing arterial CO2 tension was significant only in cortical gray matter and basal ganglia; CBF response was significant in gray and white matter, as well as in the basal ganglia.
Functional CT and constructed functional maps provide an optimal, high-resolution tool with which to visualize cerebrovascular parameters and their changes.
实施并验证螺旋滑环CT在脑血管研究中的应用。
通过单向X射线管旋转，从一项实验性的首过碘对比剂团注研究中获取连续数据，并以100毫秒的间隔重建图像。通过逐体素伽马变量拟合构建脑血容量（CBV）和脑血流量（CBF）的功能图。应用重复性研究、不同注射体积和部位以及二氧化碳激发试验来验证该技术。
CBV的平均绝对皮质灰质、白质和基底节结果在±0.8 ml/100 g范围内可重复，CBF在±20 ml/100 g每分钟范围内可重复；CBV对动脉二氧化碳张力变化的反应仅在皮质灰质和基底节中显著；CBF反应在灰质、白质以及基底节中均显著。
功能CT及构建的功能图提供了一种优化的高分辨率工具，可用于可视化脑血管参数及其变化。
