大鼠脑动脉内输注高浓度罂粟碱会损害脑动脉。
Intraarterial infusion of high-concentration papaverine damages cerebral arteries in rats.
作者信息
Yoshimura S, Hashimoto N, Goto Y, Sampei K, Tsukahara T, Iihara K
机构信息
Department of Neurosurgery, National Cardiovascular Center, Osaka, Japan.
出版信息
AJNR Am J Neuroradiol. 1996 Nov-Dec;17(10):1891-4.
PURPOSE
To determine the appropriate concentration of papaverine for therapeutic intraarterial infusion against cerebral vasospasm.
METHODS
We investigated histopathologic changes in cerebral arteries and brain tissue of normal Wistar rats that had received infusions of papaverine via the carotid artery. Rats were infused with 0.20 mL papaverine (concentration, 0.4% to 4.0%) via the internal carotid artery. Injury to the vascular wall was evaluated by transmission electron microscopy; pathologic changes in cerebral tissue were studied by light microscopy.
RESULTS
Neither brain necrosis nor brain edema was seen under light microscopy at any concentration. At 4.0% papaverine concentration, degeneration of endothelial cells and medial smooth muscle, including vacuole formation, was observed under electron microscopy. At 1.4% concentration, degeneration of endothelial cells was seen. Extravasation of Evans blue dye was noted when drug concentration exceeded 1.4%. At 0.8% concentration, no histopathologic change was noted.
CONCLUSION
On the basis of these results, we recommend a papaverine concentration of 0.8% or less for intraarterial infusion.
目的
确定用于治疗性动脉内输注以对抗脑血管痉挛的罂粟碱的合适浓度。
方法
我们研究了通过颈动脉接受罂粟碱输注的正常Wistar大鼠的脑动脉和脑组织的组织病理学变化。大鼠通过颈内动脉输注0.20 mL罂粟碱（浓度为0.4%至4.0%）。通过透射电子显微镜评估血管壁损伤；通过光学显微镜研究脑组织的病理变化。
结果
在任何浓度下，光学显微镜下均未观察到脑坏死或脑水肿。在罂粟碱浓度为4.0%时，电子显微镜下观察到内皮细胞和中层平滑肌变性，包括空泡形成。在浓度为1.4%时，可见内皮细胞变性。当药物浓度超过1.4%时，观察到伊文思蓝染料外渗。在浓度为0.8%时，未观察到组织病理学变化。
结论
基于这些结果，我们建议动脉内输注罂粟碱的浓度为0.8%或更低。
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