Milburn J M, Moran C J, Cross D T, Diringer M N, Pilgram T K, Dacey R G
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
AJNR Am J Neuroradiol. 1997 Jun-Jul;18(6):1081-5.
To measure the mean cerebral circulation time (CCT) in patients with symptomatic vasospasm stemming from subarachnoid hemorrhage and to determine any change after papaverine treatment.
We studied 27 patients who received intraarterial papaverine from November 1992 to August 1995 to determine the CCT in 59 carotid territories. CCT was measured from the first image in which contrast was seen above the supraclinoid internal carotid artery to the peak filling of parietal cortical veins. Angiograms at the time of presentation were examined in 19 of the 27 patients. A control population of 19 patients (30 carotid territories) was also studied.
The mean CCT on presentation was 6.8 seconds +/- 1.1. The prepapaverine mean CCT was 6.1 seconds +/- 1.2. The immediate postpapaverine mean CCT was 3.8 seconds +/- 0.8. CCT decreased in 58 of 59 territories treated with papaverine; the mean change was -35.7%. In eight of these patients, CCT rose on the following day to 6.1 seconds +/- 1.1. In the control group, mean CCT was 5.9 seconds +/- 0.8. The mean CCT in patients with subarachnoid hemorrhage was slightly prolonged on presentation relative to that in control subjects.
Intraarterial papaverine produces a consistent decrease in CCT in patients with vasospasm.
测量蛛网膜下腔出血所致症状性血管痉挛患者的平均脑循环时间（CCT），并确定罂粟碱治疗后的变化。
我们研究了1992年11月至1995年8月期间接受动脉内罂粟碱治疗的27例患者，以测定59个颈动脉区域的CCT。CCT从在床突上段颈内动脉上方首次见到造影剂的图像开始测量，直至顶叶皮质静脉的峰值充盈。27例患者中有19例在就诊时接受了血管造影检查。还研究了19例患者（30个颈动脉区域）的对照组。
就诊时的平均CCT为6.8秒±1.1秒。使用罂粟碱前的平均CCT为6.1秒±1.2秒。使用罂粟碱后即刻的平均CCT为3.8秒±0.8秒。59个接受罂粟碱治疗的区域中有58个区域的CCT下降；平均变化为-35.7%。其中8例患者的CCT在次日升至6.1秒±1.1秒。对照组的平均CCT为5.9秒±0.8秒。蛛网膜下腔出血患者就诊时的平均CCT相对于对照组略有延长。
动脉内罂粟碱可使血管痉挛患者的CCT持续下降。
