Mallucci C L, Parkes S E, Barber P, Powell J, Stevens M C, Walsh A R, Hockley A D
Department of Neurosurgery, Birmingham Children's Hospital, UK.
Childs Nerv Syst. 1996 Oct;12(10):582-8; discussion 589. doi: 10.1007/BF00261651.
We review our experience of meningeal tumours in patients under 16 years who were treated between 1957 and 1993. These were 16 with meningiomas (median age 12 years) and 5 with poorly differentiated malignant meningeal tumours (median age 3 years). The incidence of meningeal tumours in this period was 1.62% of all CNS tumours. There were 19 supratentorial tumours (5 intraventricular), 1 tentorial and 1 cervical. Surgical excision was complete in 12 patients and incomplete in 6; in 2 patients a biopsy only was undertaken. The remaining patient had radiological diagnosis only. All 5 patients in the group with malignant poorly differentiated tumours died (median survival 5 months), confirming the aggressive nature of these lesions. Of the 16 patients with meningiomas, 4 died during followup but 11 of the 12 meningioma patients remaining alive had complete resections. There is a strong tendency for paediatric meningeal tumours to have a supratentorial origin and intraventricular location. The female preponderance found in adults is not evident in children. Incomplete surgical excision or focal neurological deficit at presentation was associated with poor outcome.
我们回顾了1957年至1993年间接受治疗的16岁以下脑膜瘤患者的治疗经验。其中有16例脑膜瘤患者(中位年龄12岁)和5例低分化恶性脑膜瘤患者(中位年龄3岁)。在此期间,脑膜瘤的发病率占所有中枢神经系统肿瘤的1.62%。有19例幕上肿瘤(5例位于脑室内),1例小脑幕肿瘤和1例颈段肿瘤。12例患者手术切除完整,6例不完整;2例仅进行了活检。其余患者仅通过影像学诊断。恶性低分化肿瘤组的所有5例患者均死亡(中位生存期5个月),证实了这些病变的侵袭性。16例脑膜瘤患者中,4例在随访期间死亡,但存活的12例脑膜瘤患者中有11例接受了完整切除。儿童脑膜瘤有明显的幕上起源和脑室内位置的倾向。成人中女性占优势的情况在儿童中并不明显。手术切除不完整或就诊时存在局灶性神经功能缺损与预后不良相关。