Imbing F D, Viegas S F, Sánchez R L
University of Texas Medical Branch, Galveston 77555-0783, USA.
Cutis. 1996 Nov;58(5):345-8.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare angioproliferative disorder with a predilection for the head and neck region. ALHE is very rare in the extremities and even more rare in the hand, with only single cases reported in this location. We describe the occurrence of multiple lesions of ALHE on the right hand of a 26-year-old woman. We report this unusual occurrence and convey a clinical differential diagnosis with other benign and malignant conditions of the hand. All the lesions of the palm were excised out as a unit, the subungual lesion removed completely, and the involved segment of the right common digital artery excised. The tissues were processed for routine histologic examination as well as for histochemical and immunohistochemical tests. Electron microscopic study was also performed. Recurrent lesions on the same hand were also excised. Histologic examination of all the lesions revealed classic morphologic features of ALHE. The results of special studies confirmed the endothelial nature of the proliferating cells. ALHE can present as multiple lesions in the hand, and can arise in a subungual location. The possibility of larger arteries being involved should be considered. Recurrent lesions may appear months after the original presentation.
嗜酸性粒细胞增多性血管淋巴样增生（ALHE）是一种罕见的血管增殖性疾病，好发于头颈部。ALHE在四肢非常罕见，在手部更为罕见，该部位仅有个别病例报道。我们描述了一名26岁女性右手出现多发性ALHE病变的情况。我们报告这一不寻常病例，并阐述其与手部其他良恶性疾病的临床鉴别诊断。手掌的所有病变作为一个整体切除，甲下病变完全切除，右指总动脉受累节段切除。对组织进行常规组织学检查以及组织化学和免疫组织化学检测。还进行了电子显微镜研究。同一手部的复发性病变也被切除。所有病变的组织学检查均显示出ALHE的典型形态特征。特殊研究结果证实了增殖细胞的内皮性质。ALHE可表现为手部多发性病变，也可发生于甲下部位。应考虑较大动脉受累的可能性。复发性病变可能在初次出现数月后出现。
