Tan E M
Scripps Research Institute, La Jolla, California 92037, USA.
Adv Dent Res. 1996 Apr;10(1):44-6. doi: 10.1177/08959374960100010801.
Antinuclear antibodies in systemic lupus erythematosus (SLE) and related diseases have been used for characterizing nuclear antigens and for elucidating immune mechanisms that drive the autoimmune response. Each disease has its own characteristic profile of antinuclear antibodies, which has been useful for diagnostic purposes. In the biological context, concepts emerging from studies on nuclear antigens and antibodies show that the autoimmune response is antigen-driven, that autoantigens are components of subcellular particles involved in important biosynthetic functions, and that the epitopes recognized by autoantibodies are active sites or functional domain regions of these antigens. An intriguing hypothesis is that activated intracellular particles are the immunogens that drive the autoimmune response.
系统性红斑狼疮（SLE）及相关疾病中的抗核抗体已被用于鉴定核抗原，并阐明驱动自身免疫反应的免疫机制。每种疾病都有其自身抗核抗体的特征谱，这对诊断很有用。在生物学背景下，关于核抗原和抗体的研究中出现的概念表明，自身免疫反应是抗原驱动的，自身抗原是参与重要生物合成功能的亚细胞颗粒的组成成分，并且自身抗体识别的表位是这些抗原的活性位点或功能结构域区域。一个有趣的假说是，活化的细胞内颗粒是驱动自身免疫反应的免疫原。
