Webb M D
Department of Pediatric Dentistry, Baylor College of Dentistry, Dallas, Texas 75246, USA.
Anesth Prog. 1995;42(1):21-2.
Neostigmine is commonly used to reverse neuromuscular blockade. A side effect can be parasympathetic stimulation, which may result in heart block. Renal failure can decrease the clearance and increase the half-life of the drug, thus increasing the likelihood of a vagomimetic response. A case is presented where a child with renal failure developed a type I second-degree heart block after neostigmine was given.
新斯的明常用于逆转神经肌肉阻滞。其副作用可能是副交感神经刺激，这可能导致心脏传导阻滞。肾衰竭会降低药物清除率并延长其半衰期，从而增加拟迷走神经反应的可能性。本文介绍了一例肾衰竭患儿在使用新斯的明后发生I型二度心脏传导阻滞的病例。
