Press S H, Condouris G, Houpt M
Department of Pediatric Dentistry, New Jersey Dental School, Newark 07103-2400, USA.
Anesth Prog. 1995;42(3-4):131-4.
This study examined the effects of age on the behavior of mice administered one of two benzodiazepines with and without nitrous oxide. Young (3 wk +/- 3 days) and adolescent (7 wk +/- 3 days) male DBA-2 mice were administered oral diazepam (2.0 or 3.5 mg/kg), midazolam (0.75 or 1.2 mg/kg), or a placebo in combination with 50% nitrous oxide/50% oxygen, or room air. The mouse staircase model was used, where the number of rears (NR) served as an index of anxiety, and the number of steps ascended (NSA) as an index of sedation. No significant differences in the responses between the ages were noted. Nitrous oxide seemed to increase the NR and NSA, whereas the benzodiazepines alone did not affect behavior. These DBA-2 mice may represent a strain that is less sensitive to the anxiolytic-sedative effects of the benzodiazepines than are other strains.
本研究考察了年龄对给予两种苯二氮䓬类药物之一且有或无一氧化二氮情况下小鼠行为的影响。将年轻（3周±3天）和青春期（7周±3天）的雄性DBA - 2小鼠口服给予地西泮（2.0或3.5毫克/千克）、咪达唑仑（0.75或1.2毫克/千克）或安慰剂，并同时给予50%一氧化二氮/50%氧气或室内空气。采用小鼠阶梯模型，其中后肢站立次数（NR）作为焦虑指标，攀爬台阶次数（NSA）作为镇静指标。未观察到不同年龄组之间反应的显著差异。一氧化二氮似乎增加了NR和NSA，而单独使用苯二氮䓬类药物对行为没有影响。这些DBA - 2小鼠可能代表了一种比其他品系对苯二氮䓬类药物的抗焦虑 - 镇静作用敏感性更低的品系。
