挪威普通人群双胞胎样本中基因对父母报告的注意力相关问题的影响。
Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample.
作者信息
Gjone H, Stevenson J, Sundet J M
机构信息
National Centre for Child and Adolescent Psychiatry, University of Oslo, Norway.
出版信息
J Am Acad Child Adolesc Psychiatry. 1996 May;35(5):588-96; discussion 596-8. doi: 10.1097/00004583-199605000-00013.
OBJECTIVE
To assess the genetic and environmental influences on attention problems in a general population twin sample and to investigate whether there are changes in the relative genetic influence on attention problems with increasing severity.
METHOD
Parental ratings of the Child Behavior Checklist were collected from five Norwegian national cohorts of same-sex twins. The sample comprises 526 identical and 389 fraternal pairs.
RESULTS
Considerable genetic influence on attention problems was found for both sexes and across age groups (aged 5 to 9 years and 12 to 15 years). A two-parameter model with additive genetic influence and nonshared environment showed a good fit, with heritability ranging from .73 in boys aged 5 to 9 years, to .76 in girls aged 5 to 9 years. There was no change in the relative genetic influence across severity after accounting for the influence of cerebral palsy, epilepsy, and low birth weight.
CONCLUSION
The results indicate a substantial genetic influence on attention problems across sex, age, and severity.
目的
评估普通人群双胞胎样本中基因和环境对注意力问题的影响，并调查随着注意力问题严重程度增加，相对基因影响是否存在变化。
方法
从挪威五个同性双胞胎国家队列中收集父母对儿童行为检查表的评分。样本包括526对同卵双胞胎和389对异卵双胞胎。
结果
在各个年龄组（5至9岁和12至15岁）的男性和女性中均发现基因对注意力问题有显著影响。具有加性基因影响和非共享环境的双参数模型拟合良好，遗传率范围从5至9岁男孩的0.73到5至9岁女孩的0.76。在考虑脑瘫、癫痫和低出生体重的影响后，严重程度之间的相对基因影响没有变化。
结论
结果表明，基因对不同性别、年龄和严重程度的注意力问题都有重大影响。
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