McCord J M
Department of Medicine and Biochemistry, University of Colorado Health Sciences Center, Denver 80262, USA.
Nutr Rev. 1996 Mar;54(3):85-8. doi: 10.1111/j.1753-4887.1996.tb03876.x.
The human body is not equipped to eliminate excess iron. As a result, cells continuously store excess absorbed iron in a complex with the protein ferritin. This poses no great threat under normal conditions. However, under certain disease conditions, oxidative processes cause iron to be mobilized and released as Fe(II). This iron is capable of initiating lipid peroxidation, which can lead to loss of membrane structure and function.
人体没有清除多余铁的机制。因此，细胞会持续将吸收的多余铁与铁蛋白结合进行储存。在正常情况下，这不会造成太大威胁。然而，在某些疾病状态下，氧化过程会使铁被动员并以亚铁离子（Fe(II)）的形式释放出来。这种铁能够引发脂质过氧化反应，进而导致膜结构和功能的丧失。
