Liou M J, Lin J D, Huang M J, Huang J Y, Hsueh C, Jeng L B
Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Taoyuan Hsien, Taiwan, ROC.
J Formos Med Assoc. 1996 Apr;95(4):337-41.
Parathyroid carcinoma is a rare disease that usually presents with severe hypercalcemia and marked elevation of parathyroid hormone level. A 64-year-old male patient with repeated episodes of renal stones sustained chronic renal failure. Subsequently, he developed acute uremic symptoms and underwent a left upper parathyroidectomy. Parathyroid carcinoma was diagnosed after surgery. Asymptomatic hypocalcemia was the initial presentation. Protracted symptomatic hypocalcemia developed 8 months postoperatively, accompanied by an extremely high parathyroid hormone level. Delayed "bone hunger" syndrome concomitant with down-regulation of the parathyroid hormone receptors or production of parathyroid hormone with diminished bioactivity may have been the possible causes.
甲状旁腺癌是一种罕见疾病，通常表现为严重高钙血症和甲状旁腺激素水平显著升高。一名64岁男性患者反复出现肾结石，继而发展为慢性肾衰竭。随后，他出现急性尿毒症症状并接受了左上甲状旁腺切除术。术后诊断为甲状旁腺癌。最初表现为无症状性低钙血症。术后8个月出现持续性症状性低钙血症，同时伴有极高的甲状旁腺激素水平。甲状旁腺激素受体下调或生物活性降低的甲状旁腺激素产生导致的延迟性“骨饥饿”综合征可能是其原因。
