Dilli S, Pillai D N
J Chromatogr. 1977 Jul 11;137(1):111-7. doi: 10.1016/s0021-9673(00)89245-6.
Data are given for the relative electron capture response of the 2-chloroethyl derivatives of ten barbituric acids and five common anticonvulsant drugs. Results indicate that these new derivatives significantly improve the detection limits of the barbituric acids but lead to no advantages for the anticonvulsant compounds. Structural features in the two classes of compounds are believed to explain the differences in the sensitivity of detection. Linear calibration plots exist for the concentration ranges 0.1-1.0 and 1.0-10.0 microgram/ml of amobarbital.
给出了十种巴比妥酸和五种常见抗惊厥药物的2-氯乙基衍生物的相对电子捕获响应数据。结果表明，这些新衍生物显著提高了巴比妥酸的检测限，但对抗惊厥化合物并无优势。据信两类化合物的结构特征可以解释检测灵敏度的差异。对于浓度范围在0.1 - 1.0微克/毫升和1.0 - 10.0微克/毫升的异戊巴比妥，存在线性校准曲线。
